Use of any nonaspirin nonsteroidal anti-inflammatory drug during pregnancy increases the risk for spontaneous abortion more than twofold, according to a case-control study in the Canadian Medical Association Journal.Researchers used the Quebec Pregnancy Registry to identify some 4700 women who had a spontaneous abortion by 20 weeks' gestation. Each case was matched to 10 controls who did not have spontaneous abortions. Exposure to a nonaspirin NSAID during pregnancy was noted in some 7.5% of cases, but in only 2.6% of controls. After adjustment for potential confounders such as history of rheumatoid arthritis or systemic lupus, all nonaspirin NSAIDs were associated with a significantly increased risk for spontaneous abortion, the highest being with diclofenac (odds ratio, 3.09). No dose-response effect was found.
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